HRID905626

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID104477

N,N,2,2-Tetramethylpropane-1,3-diamine

C7H18N2

HCID10014651

(3-Bromomethyl-phenyl)-acetic acid methyl ester

C10H11BrO2

反应SMILES：CCCCOc1nc(N)c2nc(OC)n(CCCCBr)c2n1

HCID23158511

未命名化合物

PRODUCTS

产物

反应SMILES：CCCCOc1nc(N)c2[nH]c(=O)n(CCCCN(Cc3cccc(CC(=O)OC)c3)CC(C)(C)CN(C)C)c2n1

HCID11642652

Methyl [3-({[4-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)butyl][3-(dimethylamino)-2,2-dimethylpropyl]amino}methyl)phenyl]acetate

C30H47N7O4

PROCEDURE

实验过程

Using the compound obtained in Example 2-13 step (i) (350 mg), N,N,2,2-tetramethylpropane-1,3-diamine (1 ml), potassium carbonate (500 mg) and methyl[3-(bromomethyl)phenyl]acetate (200 mg), the same manner to Example 2-29 was conducted to give the titled compound as a white solid. Yield: 60 mg (13%); MS APCI+ve 570 (M+H).

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-85e7d5c1223b4949901487ff9682e6d8
来源数据集: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08012964B2
来源说明: uspto-grants-2011_09

反应SMILES

Br[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:14]([O:15]C)=[N:13][C:12]2[C:7]1=[N:8][C:9]([O:18][CH2:19][CH2:20][CH2:21][CH3:22])=[N:10][C:11]=2[NH2:17].[CH3:23][N:24]([CH3:31])[CH2:25][C:26]([CH3:30])([CH3:29])[CH2:27][NH2:28].C(=O)([O-])[O-].[K+].[K+].[CH3:38][O:39][C:40](=[O:50])[CH2:41][C:42]1[CH:47]=[CH:46][CH:45]=[C:44]([CH2:48]Br)[CH:43]=1>>[NH2:17][C:11]1[N:10]=[C:9]([O:18][CH2:19][CH2:20][CH2:21][CH3:22])[N:8]=[C:7]2[C:12]=1[NH:13][C:14](=[O:15])[N:6]2[CH2:5][CH2:4][CH2:3][CH2:2][N:28]([CH2:48][C:44]1[CH:43]=[C:42]([CH2:41][C:40]([O:39][CH3:38])=[O:50])[CH:47]=[CH:46][CH:45]=1)[CH2:27][C:26]([CH3:30])([CH3:29])[CH2:25][N:24]([CH3:31])[CH3:23]