HRID905627

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3939

Lithium hydroxide anhydrous

HLiO

反应SMILES：CCCCOc1nc(N)c2[nH]c(=O)n(CCCCN(Cc3cccc(CC(=O)OC)c3)CC(C)(C)CN(C)C)c2n1

HCID11642652

Methyl [3-({[4-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)butyl][3-(dimethylamino)-2,2-dimethylpropyl]amino}methyl)phenyl]acetate

C30H47N7O4

PRODUCTS

产物

反应SMILES：CCCCOc1nc(N)c2[nH]c(=O)n(CCCCN(Cc3cccc(CC(=O)O)c3)CC(C)(C)CN(C)C)c2n1

HCID11497715

未命名化合物

PROCEDURE

实验过程

Using the compound obtained in Example 2-31 (50 mg) and lithium hydroxide (15 mg), the same manner to Example 2-12 was conducted to give the titled compound as a white solid. Yield: 10 mg (21%); mp 189-190° C., MS APCI+ve 556 (M+H).

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-7070199ff0a2428ea8ed1c4640dc76b9
来源数据集: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08012964B2
来源说明: uspto-grants-2011_09

反应SMILES

[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:41])[N:6]2[CH2:16][CH2:17][CH2:18][CH2:19][N:20]([CH2:29][C:30]1[CH:31]=[C:32]([CH2:36][C:37]([O:39]C)=[O:38])[CH:33]=[CH:34][CH:35]=1)[CH2:21][C:22]([CH3:28])([CH3:27])[CH2:23][N:24]([CH3:26])[CH3:25].[OH-].[Li+]>>[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:41])[N:6]2[CH2:16][CH2:17][CH2:18][CH2:19][N:20]([CH2:29][C:30]1[CH:31]=[C:32]([CH2:36][C:37]([OH:39])=[O:38])[CH:33]=[CH:34][CH:35]=1)[CH2:21][C:22]([CH3:27])([CH3:28])[CH2:23][N:24]([CH3:26])[CH3:25]