Lithium Hydroxide → [3-({[4-(6-Amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)butyl][3-(dimethylamino)-2,2-dimethylpropyl]amino}methyl)phenyl]acetic acid

HRID 905627Notes

Reaction equation

[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:41])[N:6]2[CH2:16][CH2:17][CH2:18][CH2:19][N:20]([CH2:29][C:30]1[CH:31]=[C:32]([CH2:36][C:37]([O:39]C)=[O:38])[CH:33]=[CH:34][CH:35]=1)[CH2:21][C:22]([CH3:28])([CH3:27])[CH2:23][N:24]([CH3:26])[CH3:25].[OH-].[Li+]>>[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:41])[N:6]2[CH2:16][CH2:17][CH2:18][CH2:19][N:20]([CH2:29][C:30]1[CH:31]=[C:32]([CH2:36][C:37]([OH:39])=[O:38])[CH:33]=[CH:34][CH:35]=1)[CH2:21][C:22]([CH3:27])([CH3:28])[CH2:23][N:24]([CH3:26])[CH3:25]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 11642652Methyl [3-({[4-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)butyl][3-(dimethylamino)-2,2-dimethylpropyl]amino}methyl)phenyl]acetate

Product 1

HCID 11497715[3-({[4-(6-Amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)butyl][3-(dimethylamino)-2,2-dimethylpropyl]amino}methyl)phenyl]acetic acid

Procedure

Using the compound obtained in Example 2-31 (50 mg) and lithium hydroxide (15 mg), the same manner to Example 2-12 was conducted to give the titled compound as a white solid. Yield: 10 mg (21%); mp 189-190° C., MS APCI+ve 556 (M+H).

Sources & evidence

ORD record: ord-7070199ff0a2428ea8ed1c4640dc76b9
Source dataset: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08012964B2

Reaction notes

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