Sodium Hydroxide → HCID 23158505, compound

HRID 905640Notes

Reaction equation

HRID 905640 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH2:7]([O:11][C:12]1[N:20]=[C:19]2[C:15]([N:16]=[CH:17][N:18]2[CH2:21][CH2:22][O:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[C:30](OC)=[O:31])=[C:14]([NH2:34])[N:13]=1)[CH2:8][CH2:9][CH3:10].[OH-].[Na+]>C1COCC1>[CH2:7]([O:11][C:12]1[N:20]=[C:19]2[C:15]([N:16]=[CH:17][N:18]2[CH2:21][CH2:22][O:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[CH2:30][OH:31])=[C:14]([NH2:34])[N:13]=1)[CH2:8][CH2:9][CH3:10]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydrideHCID 23158493HCID 23158493, compound

Product 1

HCID 23158505HCID 23158505, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To a suspension of lithium aluminum hydride (74 mg, 1.9 mmol) in THF (10 ml) was added a solution of 2-butoxy-9-[2-(2-methoxycarbonylphenoxy)ethyl]adenine (500 mg, 1.4 mmol) obtained by Reference Example 5 in THF (2 ml) under ice-cooling, and the mixture was stirred at room temperature for 1 hour. 1N Aqueous sodium hydroxide solution was added thereto, followed by filtration through celite pad, and the filtrate was concentrated under reduced pressure to give 500 mg (1.4 mmol) of the titled compound as a white solid. Yield: 99%.

Workup

  1. temperaturecooling
  2. filtrationfollowed by filtration through celite pad
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-3b297728310c4c26b0e38f0ed17784af
Source dataset
uspto-grants-2011_09
Patent number
US08012964B2

Reaction notes

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