Hydrogen chloride-ethyl acetate → HCID 23071576, compound

HRID 905662Notes

Reaction equation

HRID 905662 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][N:12]([CH3:14])[C:11](=O)[CH2:10][O:9]2)=[CH:4][CH:3]=1.[ClH:16].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:16].[ClH:16].[CH3:14][N:12]1[CH2:11][CH2:10][O:9][CH:8]([C:5]2[CH:6]=[CH:7][C:2]([NH2:1])=[CH:3][CH:4]=2)[CH2:13]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 230715466-(4-Aminophenyl)-4-methyl-3-morpholinone

Product 1

HCID 23071576HCID 23071576, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

6-(4-Aminophenyl)-N-methylmorpholin-3-one was treated in the same manner as the reduction shown in Reference Example 2 and further treated with 4 M hydrogen chloride/ethyl acetate solution in ethyl acetate to obtain 4-(4-methylmorpholin-2-yl)phenylamine dihydrochloride. F: 193.

Sources & evidence

ORD record
ord-2cdb1e549b094290b5d45c0cf191115d
Source dataset
uspto-grants-2011_09
Patent number
US08012959B2

Reaction notes

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