HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 67388525, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Bromobutyronitrile | HCID 21412 | — |
| Reactant | 1-(4-Nitrophenyl)piperazine | HCID 80447 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 67388525 | HCID 67388525 | — |
Reaction Steps
1-(4-Nitrophenyl)piperazine and 4-bromobutyronitrile were allowed to undergo the reaction under heating in 1-methyl-2-pyrrolidone in the presence of potassium carbonate. The resulting compound was allowed to react with polyphosphoric acid under heating and then subjected to catalytic hydrogenation in the same manner as shown in Reference Example 3 to obtain 4-[4-(4-aminophenyl)piperazin-1-yl]butanamide. F: 263.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08012959B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-f9da9e0a18614fe7881b17f8ec9943d4 |
| Source note | uspto-grants-2011_09 |