Potassium Carbonate → HCID 67388525, compound

HRID 905667Notes

Reaction equation

HRID 905667 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-])=O.Br[CH2:17][CH2:18][CH2:19][C:20]#[N:21].C(=O)([O-])[O-:23].[K+].[K+]>CN1CCCC1=O>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([CH2:17][CH2:18][CH2:19][C:20]([NH2:21])=[O:23])[CH2:12][CH2:11]2)=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 214124-BromobutyronitrileHCID 804471-(4-Nitrophenyl)piperazine

Product 1

HCID 67388525HCID 67388525, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

1-(4-Nitrophenyl)piperazine and 4-bromobutyronitrile were allowed to undergo the reaction under heating in 1-methyl-2-pyrrolidone in the presence of potassium carbonate. The resulting compound was allowed to react with polyphosphoric acid under heating and then subjected to catalytic hydrogenation in the same manner as shown in Reference Example 3 to obtain 4-[4-(4-aminophenyl)piperazin-1-yl]butanamide. F: 263.

Workup

  1. customthe reaction
  2. temperatureunder heating

Sources & evidence

ORD record
ord-f9da9e0a18614fe7881b17f8ec9943d4
Source dataset
uspto-grants-2011_09
Patent number
US08012959B2

Reaction notes

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