914389-14-3 → HCID 67404113, compound

HRID 905702Notes

Reaction equation

HRID 905702 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([N:8]=[C:9]2[N:13]([CH2:14][CH2:15][NH:16][C:17]([NH:19][CH3:20])=[O:18])[C:12]([C:21]3[CH:26]=[CH:25][C:24]([N:27]4[CH2:32][CH2:31][O:30][CH2:29][CH2:28]4)=[CH:23][CH:22]=3)=[CH:11][S:10]2)[CH:5]=[CH:6][CH:7]=1.[BrH:33].CC(O)=O>C(Cl)(Cl)Cl>[BrH:33].[F:1][C:2]1[CH:3]=[C:4]([N:8]=[C:9]2[N:13]([CH2:14][CH2:15][NH:16][C:17]([NH:19][CH3:20])=[O:18])[C:12]([C:21]3[CH:26]=[CH:25][C:24]([N:27]4[CH2:32][CH2:31][O:30][CH2:29][CH2:28]4)=[CH:23][CH:22]=3)=[CH:11][S:10]2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 11949660914389-14-3HCID 21893785Acetic Acid Mixture with Hydrobromic Acid

Product 1

HCID 67404113HCID 67404113, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a suspension of N-{2-[2-[(3-fluorophenyl)imino]-4-(4-morpholin-4-ylphenyl)-1,3-thiazol-3(2H)-yl]ethyl}-N′-methylurea (455 mg) in chloroform (50 ml) was added 25% HBr/AcOH (0.32 g), and the mixture was stirred to dissolve for 30 minutes. The solvent was removed, and then thereto was added diethylether and a precipitate was filtered to give crystals (520 mg) of which a melting point was 191 to 193° C.

Workup

  1. dissolutionto dissolve for 30 minutes
  2. customThe solvent was removed
  3. additionwas added diethylether
  4. filtrationa precipitate was filtered

Sources & evidence

ORD record
ord-a1ce21efb7a1445883c7553324aaa4e3
Source dataset
uspto-grants-2011_09
Patent number
US08012971B2

Reaction notes

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