Water → HCID 59340055, compound

HRID 905915Notes

Reaction equation

HRID 905915 reaction equation
FC(F)(F)C(O)=O.[C:8]([C:10]1[CH:11]=[C:12]([C:16]2[CH:25]=[C:24]3[C:19]([C:20]([OH:39])=[C:21]([C:28]([NH:30][CH2:31][C:32]([O:34]C(C)(C)C)=[O:33])=[O:29])[C:22](=[O:27])[N:23]3[CH3:26])=[CH:18][CH:17]=2)[CH:13]=[CH:14][CH:15]=1)#[N:9].O>ClCCl>[C:8]([C:10]1[CH:11]=[C:12]([C:16]2[CH:25]=[C:24]3[C:19]([C:20]([OH:39])=[C:21]([C:28]([NH:30][CH2:31][C:32]([OH:34])=[O:33])=[O:29])[C:22](=[O:27])[N:23]3[CH3:26])=[CH:18][CH:17]=2)[CH:13]=[CH:14][CH:15]=1)#[N:9]

Participants

5

Reactant 3

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 59340067HCID 59340067, compound

Product 1

HCID 59340055HCID 59340055, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (4.00 ml, 54 mmol) was added to a suspension of tert-butyl 2-(7-(3-cyanophenyl)-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetate (0.162 g, 0.37 mmol) in dichloromethane (2.00 ml). After stirring for one hour at room temperature water was added and the solids formed were collected by filtration. The solids were washed with water, ether, dried in a vacuum oven at 50° C. to afford off-white solids in 74% yield.

Workup

  1. additionwas added
  2. customthe solids formed
  3. filtrationwere collected by filtration
  4. washThe solids were washed with water, ether
  5. customdried in a vacuum oven at 50° C.
  6. customto afford off-white solids in 74% yield

Sources & evidence

ORD record
ord-a99bac082a3841c99a2615bcaf59852b
Source dataset
uspto-grants-2011_09
Patent number
US08012968B2

Reaction notes

Loading…