Phenethyl isocyanate → 1-phenethyl-3-[5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-urea

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Reaction Steps

A solution of 5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamine (0.260 g, 0.98 mmol) in 15 mL of dichloromethane was cooled to −30° C. Phenethyl isocyanate (0.21 g, 1.5 mmol) was added, and the resulting solution was stirred at room temperature for 14 h, then concentrated to a residue. Column chromatography afforded 0.220 g (55%) of 1-phenethyl-3-[5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-urea.

Provenance & Evidence