Hydrochloric Acid → HCID 67385864, compound

HRID 905948Notes

Reaction equation

HRID 905948 reaction equation
C(OC(=O)[NH:7][C@@H:8]1[CH2:13][C@@H:12]([CH3:14])[CH2:11][N:10]([C:15](=[O:17])[CH3:16])[CH2:9]1)(C)(C)C.[ClH:19].O1CCOCC1>C(Cl)Cl>[ClH:19].[NH2:7][C@@H:8]1[CH2:13][C@@H:12]([CH3:14])[CH2:11][N:10]([C:15](=[O:17])[CH3:16])[CH2:9]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 67385284HCID 67385284, compound

Product 1

HCID 67385864HCID 67385864, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

((3R,5R)-1-Acetyl-5-methyl-piperidin-3-yl)-carbamic acid tert-butyl ester (0.5 g, 1.971 mmol) was dissolved in DCM (15) and HCl 4M in dioxane (2.5 mL, 10 mmol) was added. The resulting colorless solution was stirred at RT until precipitation of a solid was observed. The solvent was evaporated and the residue was dried under high vacuum to give 0.45 g of 1-((3R,5R)-3-amino-5-methyl-piperidin-1-yl)-ethanone hydrochloride as an off-white solid (>95% yield).

Workup

  1. customThe solvent was evaporated
  2. customthe residue was dried under high vacuum

Sources & evidence

ORD record
ord-f69c287340624e3f8eadf42ad8d019ca
Source dataset
uspto-grants-2011_09
Patent number
US08012974B2

Reaction notes

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