反应详情

To a flask containing HCl (37%, 5 mL) and methanol (155 mL) was added cis 2-[3-(tert-butyl-dimethyl-silanyloxy)-cyclopentyl]-5,6-dichloro-isoindole-1,3-dione (1.7 g, 4.1 mmol). The mixture was placed in an ultrasound bath until all of the solid had dissolved (15 minutes) then evaporated to give cis 5,6-dichloro-2-(3-hydroxy-cyclopentyl)-2,3-dihydro-1H-isoindole-1,3-diol (1.172 g, 95% yield).

1. customThe mixture was placed in an ultrasound bath
2. dissolutionuntil all of the solid had dissolved (15 minutes)
3. customthen evaporated