HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-sec-butylamine → 4-(aminocarbonyl)-2-(ethylamino)-5-{[(1R)-1-methylpropyl]amino}benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-sec-butylamine | HCID 2724537 | — |
| Reactant | ethyl 2-bromo-4-cyano-5-{[(1R)-1-methylpropyl]amino}benzoate | HCID 67404527 | — |
| Reactant | ethyl 4-cyano-2-(ethylamino)-5-{[(1R)-1-methylpropyl]amino}benzoate | HCID 67405722 | — |
| Product | 4-(aminocarbonyl)-2-(ethylamino)-5-{[(1R)-1-methylpropyl]amino}benzoic acid | HCID 57748590 | — |
Reaction Steps
Synthesized according to the method of reagent preparation 50 by using (1R)-1-methylpropylamine in step 1 then following step 2 with the conversion of ethyl 2-bromo-4-cyano-5-{[(1R)-1-methylpropyl]amino}benzoate to ethyl 4-cyano-2-(ethylamino)-5-{[(1R)-1-methylpropyl]amino}benzoate according to the method described in step 1 then proceeding through steps 3 and 4. MS (EI) for C14H21N3O3: 280 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08012956B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-445f68c7ef214569aad75372bc727aca |
| Source note | uspto-grants-2011_09 |