2,5-Diazabicyclo(2.2.2)octane dihydrochloride → 4-(5-Isopropyl-2,5-diazabicyclo[2.2.2]octan-2-yl)aniline

HRID 906211Notes

Reaction equation

HRID 906211 reaction equation
[CH:1]([N:4]1[CH2:9][C@@H:8]2[CH2:10][C@H:5]1[CH2:6][N:7]2[C:11]1[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=1)([CH3:3])[CH3:2].Cl.Cl.[CH:20]12CCC(NC1)CN2>>[CH:1]([N:4]1[CH2:9][CH:8]2[CH2:20][CH2:10][CH:5]1[CH2:6][N:7]2[C:11]1[CH:12]=[CH:13][C:14]([NH2:17])=[CH:15][CH:16]=1)([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 229243902,5-Diazabicyclo(2.2.2)octane dihydrochlorideHCID 579639114-((1S,4S)-5-Isopropyl-2,5-diaza-bicyclo[2.2.1]hept-2-yl)-phenylamine

Product 1

HCID 579639214-(5-Isopropyl-2,5-diazabicyclo[2.2.2]octan-2-yl)aniline

Procedure

This compound is prepared according to the same procedure as described for Intermediate 7 using 2,5-diazabicyclo[2.2.2]octane dihydrochloride (J. Heterocycl. Chem, 1974, 11, 449-451).

Workup

  1. customThis compound is prepared

Sources & evidence

ORD record
ord-69d7951286944b21aaff80d3b4265701
Source dataset
uspto-grants-2011_09
Patent number
US08012983B2

Reaction notes

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