反应详情

The reaction mixture comprising one equivalent of 5,5-dimethyl-3,4,5,6-tetrahydro(1H)pyrimidine-2-thione and 1.2 equivalents of iodomethane in methanol (10 ml/g of thio-urea) is heated under reflux for 5 hours. After cooling down, the methanol is evaporated off under reduced pressure in order to quantitatively produce the product. The precipitate can then be washed in acetone or petroleum ether.

1. temperatureunder reflux for 5 hours
2. temperatureAfter cooling down
3. customthe methanol is evaporated off under reduced pressure in order
4. customto quantitatively produce the product
5. washThe precipitate can then be washed in acetone