2-Chloro-4-(5-chloro-thiophen-2-yl)-6-trifluoromethyl-pyrimidine → 4-(5-Chloro-thiophen-2-yl)-2-(4-iodo-imidazol-1-yl)-6-trifluoromethyl-pyrimidine

HRID 906248Notes

Reaction equation

HRID 906248 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[S:9][C:10]([Cl:13])=[CH:11][CH:12]=2)[CH:5]=[C:4]([C:14]([F:17])([F:16])[F:15])[N:3]=1.[I:18][C:19]1[N:20]=[CH:21][NH:22][CH:23]=1>>[Cl:13][C:10]1[S:9][C:8]([C:6]2[CH:5]=[C:4]([C:14]([F:17])([F:16])[F:15])[N:3]=[C:2]([N:22]3[CH:23]=[C:19]([I:18])[N:20]=[CH:21]3)[N:7]=2)=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 866246272-Chloro-4-(5-chloro-thiophen-2-yl)-6-trifluoromethyl-pyrimidineHCID 178506559HCID 178506559, compound

Product 1

HCID 673933674-(5-Chloro-thiophen-2-yl)-2-(4-iodo-imidazol-1-yl)-6-trifluoromethyl-pyrimidine

Procedure

The title compound was prepared from 2-chloro-4-(5-chloro-thiophen-2-yl)-6-trifluoromethyl-pyrimidine (example A.1) (1.2 g, 4.0 mmol) and commercially available 4-iodo-imidazole (0.85 g, 4.4 mmol) according to the general procedure Ia. Obtained as an off-white solid (1.78 g, 97%). MS (ISP) 457.0 [(M+H)+]; mp 251° C.

Sources & evidence

ORD record
ord-aca931d2744d4242a01e960515aae424
Source dataset
uspto-grants-2011_09
Patent number
US08012986B2

Reaction notes

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