HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4-(5-chloro-thiophen-2-yl)-6-trifluoromethyl-pyrimidine → 4-(5-Chloro-thiophen-2-yl)-2-(4-iodo-imidazol-1-yl)-6-trifluoromethyl-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4-(5-chloro-thiophen-2-yl)-6-trifluoromethyl-pyrimidine | HCID 86624627 | — |
| Reactant | HCID 178506559 | HCID 178506559 | — |
| Product | 4-(5-Chloro-thiophen-2-yl)-2-(4-iodo-imidazol-1-yl)-6-trifluoromethyl-pyrimidine | HCID 67393367 | — |
Reaction Steps
The title compound was prepared from 2-chloro-4-(5-chloro-thiophen-2-yl)-6-trifluoromethyl-pyrimidine (example A.1) (1.2 g, 4.0 mmol) and commercially available 4-iodo-imidazole (0.85 g, 4.4 mmol) according to the general procedure Ia. Obtained as an off-white solid (1.78 g, 97%). MS (ISP) 457.0 [(M+H)+]; mp 251° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08012986B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-aca931d2744d4242a01e960515aae424 |
| Source note | uspto-grants-2011_09 |