3-Fluoro-4-methoxyaniline → 1,1-Dimethylethyl 4-{[3-fluoro-4-(methyloxy)phenyl]amino}-1-piperidinecarboxylate

HRID 906349Notes

Reaction equation

HRID 906349 reaction equation
O=[C:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4][CH2:3]1.[F:15][C:16]1[CH:17]=[C:18]([CH:20]=[CH:21][C:22]=1[O:23][CH3:24])[NH2:19].FC1C=CC(NC2CCN(C(OC(C)(C)C)=O)CC2)=CC=1OC>>[F:15][C:16]1[CH:17]=[C:18]([NH:19][CH:2]2[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4][CH2:3]2)[CH:20]=[CH:21][C:22]=1[O:23][CH3:24]

Participants

4

Reactant 3

HCID 5811103-Fluoro-4-methoxyanilineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 576995241,1-Dimethylethyl 4-{[4-fluoro-3-(methyloxy)phenyl]amino}-1-piperidinecarboxylate

Product 1

HCID 576995191,1-Dimethylethyl 4-{[3-fluoro-4-(methyloxy)phenyl]amino}-1-piperidinecarboxylate

Procedure

The title compound was prepared from 1,1-dimethylethyl 4-oxo-1-piperidinecarboxylate and 3-fluoro-4-methoxyaniline using a method similar to that described for D9 in Description 9.

Sources & evidence

ORD record
ord-785565db9bb44f7a8ef61d89dd315045
Source dataset
uspto-grants-2011_09
Patent number
US08012981B2

Reaction notes

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