tert-Butyl (2S)-2-methylpiperazine-1-carboxylate → tert-Butyl (2S)-4-{[6-bromo-1-oxo-2-(phenylsulfonyl)-1,2-dihydroisoquinolin-4-yl]methyl}-2-methylpiperazine-1-carboxylate

HRID 906434Notes

Reaction equation

HRID 906434 reaction equation
[CH3:1][C@H:2]1[CH2:7][NH:6][CH2:5][CH2:4][N:3]1[C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9].[Br:15][C:16]1[CH:17]=[C:18]2[C:23](=[CH:24][CH:25]=1)[C:22](=[O:26])[N:21]([S:27]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)(=[O:29])=[O:28])[CH:20]=[C:19]2[CH2:36]Br>>[Br:15][C:16]1[CH:17]=[C:18]2[C:23](=[CH:24][CH:25]=1)[C:22](=[O:26])[N:21]([S:27]([C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1)(=[O:29])=[O:28])[CH:20]=[C:19]2[CH2:36][N:6]1[CH2:5][CH2:4][N:3]([C:8]([O:10][C:11]([CH3:13])([CH3:12])[CH3:14])=[O:9])[C@@H:2]([CH3:1])[CH2:7]1

Participants

3

Reactant 2

HCID 10081508tert-Butyl (2S)-2-methylpiperazine-1-carboxylateHCID 671303306-Bromo-4-(bromomethyl)-2-(phenylsulfonyl)isoquinolin-1(2H)-one

Product 1

HCID 67130295tert-Butyl (2S)-4-{[6-bromo-1-oxo-2-(phenylsulfonyl)-1,2-dihydroisoquinolin-4-yl]methyl}-2-methylpiperazine-1-carboxylate

Procedure

The subtitle compound was prepared by the method of Example 11e using (S)-tert-butyl 2-methylpiperazine-1-carboxylate and 6-bromo-4-(bromomethyl)-2-(phenylsulfonyl)isoquinolin-1(2H)-one (Example 11d)

Sources & evidence

ORD record
ord-60dd2a699c824abc8583d4e65a9affcb
Source dataset
uspto-grants-2011_09
Patent number
US08012980B2

Reaction notes

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