反应详情

A solution of 6-bromoisoquinolin-1(2H)-one (10 g) in chlorosulfuric acid (29.9 mL) was heated at 90° C. for 2 h. Chlorosulfuric acid (29.9 mL) was added, and the reaction mixture was poured onto ice (CAUTION). The resulting solid was filtered, washed with water, and dried in vacuo (25° C.) to give the subtitle compound as a beige solid (12.31 g).

1. additionthe reaction mixture was poured onto ice (CAUTION)
2. filtrationThe resulting solid was filtered
3. washwashed with water
4. customdried in vacuo (25° C.)