Chlorosulfonic acid → 6-Bromo-1-oxo-1,2-dihydroisoquinoline-4-sulfonyl chloride

Participants

Reaction Steps

A solution of 6-bromoisoquinolin-1(2H)-one (10 g) in chlorosulfuric acid (29.9 mL) was heated at 90° C. for 2 h. Chlorosulfuric acid (29.9 mL) was added, and the reaction mixture was poured onto ice (CAUTION). The resulting solid was filtered, washed with water, and dried in vacuo (25° C.) to give the subtitle compound as a beige solid (12.31 g).

Provenance & Evidence