HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-Bromo-1-(bromomethyl)-2-chlorobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Azobisisobutyronitrile | HCID 6547 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 4-Bromo-2-chlorotoluene | HCID 2735554 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | 4-Bromo-1-(bromomethyl)-2-chlorobenzene | HCID 21914486 | 55.3% |
Reaction Steps
5.0 g of 2-chloro-4-bromotoluene are dissolved in 120 ml of CCl4. 4.3 g of NBS and 1.6 g of AIBN are added. The mixture is heated at reflux for 15 hours, water is added, the two phases are separated and then extraction is carried out with CH2Cl2. Purification is carried out by chromatography on a silica column eluted with petroleum ether. 3.8 g of liquid are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08012991B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-1d17187996294ba3befa45d30c8cc81c |
| Source note | uspto-grants-2011_09 |