反应详情

5.0 g of 2-chloro-4-bromotoluene are dissolved in 120 ml of CCl4. 4.3 g of NBS and 1.6 g of AIBN are added. The mixture is heated at reflux for 15 hours, water is added, the two phases are separated and then extraction is carried out with CH2Cl2. Purification is carried out by chromatography on a silica column eluted with petroleum ether. 3.8 g of liquid are obtained.

1. temperatureThe mixture is heated
2. temperatureat reflux for 15 hours
3. customthe two phases are separated
4. extractionextraction
5. customPurification
6. washeluted with petroleum ether