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HRID906826

反应详情

EQUATION

反应方程式

HRID 906826 的结构方程式

REACTANTS

反应物

2
结构：Nc1nc(-c2cccc(Br)c2)cs1
HCID723330

4-(3-Bromophenyl)-1,3-thiazol-2-amine

C9H7BrN2S

结构：CC1(C(=O)O)CC2([N+](=O)[O-])c3ccccc3C1c1ccccc12
HCID59698574

未命名化合物

PRODUCTS

生成物

1
结构：NC(=O)C1CC2([N+](=O)[O-])c3ccccc3C1c1ccccc12
HCID86613897

未命名化合物

收率 92.4%

PROCEDURE

实验过程

In a similar manner to Example 1, Step 2, the coupling reaction of 15-methyl-8-nitrotetracyclo[6.6.2.02,7.09,14]hexadeca-2,4,6,9,11,13-hexaene-15-carboxylic acid (200 mg, 0.647 mmol) and 4-(3-bromo-phenyl)-thiazol-2-ylamine (214 mg, 0.841 mmol) afforded 15-methyl-N-[4-(3-bromo-phenyl)-thiazol-2-yl]-]-8-nitrotetracyclo[6.6.2.02,7.09,14]hexadeca-2,4,6,9,11,13-hexaene-15-carboxamide (176 mg, 49% yield). LC/MS (m/z 548.08 (M+H)+); HPLC Rt: 4.385 min.