HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(3-Bromophenyl)-1,3-thiazol-2-amine → 8-Nitrotetracyclo[6.6.2.02,7.09,14]hexadeca-2,4,6,9,11,13-hexaene-15-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(3-Bromophenyl)-1,3-thiazol-2-amine | HCID 723330 | — |
| Reactant | 9-Nitro-9,10-dihydro-11-methyl-9,10-ethanoanthracene-11-carboxylic acid | HCID 59698574 | — |
| Product | 8-Nitrotetracyclo[6.6.2.02,7.09,14]hexadeca-2,4,6,9,11,13-hexaene-15-carboxamide | HCID 86613897 | 92.4% |
Reaction Steps
In a similar manner to Example 1, Step 2, the coupling reaction of 15-methyl-8-nitrotetracyclo[6.6.2.02,7.09,14]hexadeca-2,4,6,9,11,13-hexaene-15-carboxylic acid (200 mg, 0.647 mmol) and 4-(3-bromo-phenyl)-thiazol-2-ylamine (214 mg, 0.841 mmol) afforded 15-methyl-N-[4-(3-bromo-phenyl)-thiazol-2-yl]-]-8-nitrotetracyclo[6.6.2.02,7.09,14]hexadeca-2,4,6,9,11,13-hexaene-15-carboxamide (176 mg, 49% yield). LC/MS (m/z 548.08 (M+H)+); HPLC Rt: 4.385 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08013004B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-c7bf4c14c1b24d2e94fe6dfa1d742078 |
| Source note | uspto-grants-2011_09 |