Lithium Carbonate → HCID 67390298, compound

HRID 906983Notes

Reaction equation

HRID 906983 reaction equation
[CH3:1][C@H:2]1[C@@:6]([CH3:8])([OH:7])[CH2:5][CH2:4][NH:3]1.F[C:10]1[CH:17]=[CH:16][C:13]([C:14]#[N:15])=[CH:12][C:11]=1[C:18]([F:21])([F:20])[F:19].C(=O)([O-])[O-].[Li+].[Li+]>>[OH:7][C@@:6]1([CH3:8])[CH2:5][CH2:4][N:3]([C:10]2[CH:17]=[CH:16][C:13]([C:14]#[N:15])=[CH:12][C:11]=2[C:18]([F:19])([F:21])[F:20])[C@H:2]1[CH3:1]

Participants

4

Reactant 3

HCID 11125Lithium CarbonateHCID 1442554-Fluoro-3-(trifluoromethyl)benzonitrileHCID 59556870(2S,3S)-2,3-dimethylpyrrolidin-3-ol

Product 1

HCID 67390298HCID 67390298, compound

Procedure

By an operation in the same manner as in Example 1 and using (2S,3S)-2,3-dimethylpyrrolidin-3-ol 0.5 oxalate (228 mg), 4-fluoro-3-(trifluoromethyl)benzonitrile (397 mg) and lithium carbonate (206 mg), the title compound was obtained as a colorless oil (yield: 220 mg, yield: 55%).

Sources & evidence

ORD record
ord-a35b70ff548a4cc6814cb3c2c9a4914f
Source dataset
uspto-grants-2011_09
Patent number
US08013008B2

Reaction notes

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