Lithium Carbonate → HCID 24986667, compound

HRID 906985Notes

Reaction equation

HRID 906985 reaction equation
[CH3:1][C@H:2]1[C@@:6]([CH3:8])([OH:7])[CH2:5][CH2:4][NH:3]1.[F:9][C:10]1[CH:17]=[C:16](F)[CH:15]=[C:14]([F:19])[C:11]=1[C:12]#[N:13].C(=O)([O-])[O-].[Li+].[Li+]>>[F:9][C:10]1[CH:17]=[C:16]([N:3]2[CH2:4][CH2:5][C@@:6]([OH:7])([CH3:8])[C@@H:2]2[CH3:1])[CH:15]=[C:14]([F:19])[C:11]=1[C:12]#[N:13]

Participants

4

Reactant 3

HCID 11125Lithium CarbonateHCID 7371772,4,6-TrifluorobenzonitrileHCID 59556870(2S,3S)-2,3-dimethylpyrrolidin-3-ol

Product 1

HCID 24986667HCID 24986667, compound

Procedure

By an operation in the same manner as in Example 1 and using (2S,3S)-2,3-dimethylpyrrolidin-3-ol 0.5 oxalate (300 mg), 2,4,6-trifluorobenzonitrile (882 mg) and lithium carbonate (276 mg), the title compound was obtained as a colorless solid (yield: 263 mg, yield: 56%).

Sources & evidence

ORD record
ord-aeda77b977ee4840925c20ab74827a00
Source dataset
uspto-grants-2011_09
Patent number
US08013008B2

Reaction notes

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