反应详情

By an operation in the same manner as in Example 1 and using (2S,3S)-3-ethyl-2-isopropylpyrrolidin-3-ol 0.5 oxalate (162 mg), 2-chloro-4-fluorobenzonitrile (125 mg) and lithium carbonate (126 mg), the title compound was obtained as pale-brown oil (yield: 151 mg, yield: 65%).