HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Carbonate → 2-chloro-4-[(2S,3S)-3-ethyl-3-hydroxy-2-isopropylpyrrolidin-1-yl]benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Carbonate | HCID 11125 | — |
| Reactant | 2-Chloro-4-fluorobenzonitrile | HCID 109000 | — |
| Reactant | (2S,3S)-3-ethyl-2-isopropylpyrrolidin-3-ol | HCID 59273069 | — |
| Product | 2-chloro-4-[(2S,3S)-3-ethyl-3-hydroxy-2-isopropylpyrrolidin-1-yl]benzonitrile | HCID 59273005 | — |
Reaction Steps
By an operation in the same manner as in Example 1 and using (2S,3S)-3-ethyl-2-isopropylpyrrolidin-3-ol 0.5 oxalate (162 mg), 2-chloro-4-fluorobenzonitrile (125 mg) and lithium carbonate (126 mg), the title compound was obtained as pale-brown oil (yield: 151 mg, yield: 65%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08013008B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-b78dcf0fbfa44069964c976eab5819b3 |
| Source note | uspto-grants-2011_09 |