Lithium Carbonate → HCID 59273067, compound

HRID 907017Notes

Reaction equation

HRID 907017 reaction equation
[CH:1]1([C@:4]2([OH:12])[CH2:8][CH2:7][NH:6][C@H:5]2[CH:9]([CH3:11])C)CC1.F[C:14]1[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[C:16]([C:22]([F:25])([F:24])[F:23])[CH:15]=1.C(=O)([O-])[O-].[Li+].[Li+]>>[CH2:9]([C@H:5]1[C@:4]([OH:12])([CH3:1])[CH2:8][CH2:7][N:6]1[C:14]1[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[C:16]([C:22]([F:23])([F:25])[F:24])[CH:15]=1)[CH3:11]

Participants

4

Reactant 3

HCID 11125Lithium CarbonateHCID 6050854-Fluoro-2-(trifluoromethyl)benzonitrileHCID 59273011(2S,3R)-3-cyclopropyl-2-isopropylpyrrolidin-3-ol

Product 1

HCID 59273067HCID 59273067, compound

Procedure

By an operation in the same manner as in Example 1 and using (2S,3S)-2-ethyl-3-methylpyrrolidin-3-ol 0.5 oxalate (200 mg), 4-fluoro-2-(trifluoromethyl)benzonitrile (325 mg) and lithium carbonate (187 mg), the title compound was obtained as pale-yellow oil (yield: 306.6 mg, yield: 90%).

Sources & evidence

ORD record
ord-f3b05b2445cf47abb164a320e9ece7a9
Source dataset
uspto-grants-2011_09
Patent number
US08013008B2

Reaction notes

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