Lithium Carbonate → HCID 59273071, compound

HRID 907018Notes

Reaction equation

HRID 907018 reaction equation
[CH:1]1([C@:4]2([OH:12])[CH2:8][CH2:7][NH:6][C@H:5]2[CH:9]([CH3:11])C)CC1.[Cl:13][C:14]1[CH:21]=[C:20](F)[CH:19]=[CH:18][C:15]=1[C:16]#[N:17].C(=O)([O-])[O-].[Li+].[Li+]>>[Cl:13][C:14]1[CH:21]=[C:20]([N:6]2[CH2:7][CH2:8][C@@:4]([OH:12])([CH3:1])[C@@H:5]2[CH2:9][CH3:11])[CH:19]=[CH:18][C:15]=1[C:16]#[N:17]

Participants

4

Reactant 3

HCID 11125Lithium CarbonateHCID 1090002-Chloro-4-fluorobenzonitrileHCID 59273011(2S,3R)-3-cyclopropyl-2-isopropylpyrrolidin-3-ol

Product 1

HCID 59273071HCID 59273071, compound

Procedure

By an operation in the same manner as in Example 1 and using (2S,3S)-2-ethyl-3-methylpyrrolidin-3-ol 0.5 oxalate (195 mg), 2-chloro-4-fluorobenzonitrile (320 mg) and lithium carbonate (200 mg), the title compound was obtained as a colorless solid (yield: 221.4 mg, yield: 75%).

Sources & evidence

ORD record
ord-b513727058674c0d97ea36b3dd41c63f
Source dataset
uspto-grants-2011_09
Patent number
US08013008B2

Reaction notes

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