Lithium Carbonate → HCID 59273041, compound

HRID 907029Notes

Reaction equation

HRID 907029 reaction equation
[CH:1]1([C@:4]2([OH:12])[CH2:8][CH2:7][NH:6][C@H:5]2[CH:9]([CH3:11])C)[CH2:3][CH2:2]1.F[C:14]1[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[C:16]([O:22][CH3:23])[CH:15]=1.C(=O)([O-])[O-].[Li+].[Li+]>>[CH:1]1([C@:4]2([OH:12])[CH2:8][CH2:7][N:6]([C:14]3[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[C:16]([O:22][CH3:23])[CH:15]=3)[C@H:5]2[CH2:9][CH3:11])[CH2:2][CH2:3]1

Participants

4

Reactant 3

HCID 11125Lithium CarbonateHCID 27833294-Fluoro-2-methoxybenzonitrileHCID 59273011(2S,3R)-3-cyclopropyl-2-isopropylpyrrolidin-3-ol

Product 1

HCID 59273041HCID 59273041, compound

Procedure

By an operation in the same manner as in Example 1 and using (2S,3R)-3-cyclopropyl-2-ethylpyrrolidin-3-ol 0.5 oxalate (185 mg), 4-fluoro-2-methoxybenzonitrile (290 mg) and lithium carbonate (198 mg), the title compound was obtained as a pale-yellow solid (yield: 144 mg, yield: 55%).

Sources & evidence

ORD record
ord-96622dad1a224252bb9041e34c1e0692
Source dataset
uspto-grants-2011_09
Patent number
US08013008B2

Reaction notes

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