Lithium Carbonate → HCID 67391942, compound

HRID 907031Notes

Reaction equation

HRID 907031 reaction equation
C1([C@]2(O)[CH2:8][CH2:7][NH:6][C@H:5]2[CH:9]([CH3:11])[CH3:10])CC1.F[C:14]1[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[C:16]([C:22]([F:25])([F:24])[F:23])[CH:15]=1.[C:26](=[O:29])([O-])[O-].[Li+].[Li+]>>[OH:29][C@H:26]1[C:9]([CH3:11])([CH3:10])[CH2:5][N:6]([C:14]2[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[C:16]([C:22]([F:25])([F:24])[F:23])[CH:15]=2)[C@@H:7]1[CH3:8]

Participants

4

Reactant 3

HCID 11125Lithium CarbonateHCID 6050854-Fluoro-2-(trifluoromethyl)benzonitrileHCID 59273011(2S,3R)-3-cyclopropyl-2-isopropylpyrrolidin-3-ol

Product 1

HCID 67391942HCID 67391942, compound

Procedure

By an operation in the same manner as in Example 53 and using (2R,3S)-2,4,4-trimethylpyrrolidin-3-ol 0.5 oxalate (146 mg), 4-fluoro-2-(trifluoromethyl)benzonitrile (255 mg) and lithium carbonate (140 mg), the title compound was obtained as a colorless solid (yield: 106 mg, yield: 42%).

Sources & evidence

ORD record
ord-e45ce971443c43cd9625e7a7b6df378f
Source dataset
uspto-grants-2011_09
Patent number
US08013008B2

Reaction notes

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