Lithium Carbonate → HCID 67389475, compound

HRID 907032Notes

Reaction equation

HRID 907032 reaction equation
C1([C@]2(O)[CH2:8][CH2:7][NH:6][C@H:5]2[CH:9]([CH3:11])[CH3:10])CC1.[F:13][C:14]1[C:21]([CH3:22])=[C:20](F)[CH:19]=[CH:18][C:15]=1[C:16]#[N:17].[C:24](=[O:27])([O-])[O-].[Li+].[Li+]>>[F:13][C:14]1[C:21]([CH3:22])=[C:20]([N:6]2[CH2:5][C:9]([CH3:11])([CH3:10])[C@H:24]([OH:27])[C@H:7]2[CH3:8])[CH:19]=[CH:18][C:15]=1[C:16]#[N:17]

Participants

4

Reactant 3

HCID 11125Lithium CarbonateHCID 113441192,4-Difluoro-3-methylbenzonitrileHCID 59273011(2S,3R)-3-cyclopropyl-2-isopropylpyrrolidin-3-ol

Product 1

HCID 67389475HCID 67389475, compound

Procedure

By an operation in the same manner as in Example 53 and using (2RS,3SR)-2,4,4-trimethylpyrrolidin-3-ol 0.5 oxalate (214 mg), 2,4-difluoro-3-methylbenzonitrile (240 mg) and lithium carbonate (246 mg), the title compound was obtained as a colorless solid (yield: 112 mg, yield: 35%).

Sources & evidence

ORD record
ord-7b8cb2d6715e4b8fbe74037aee664b11
Source dataset
uspto-grants-2011_09
Patent number
US08013008B2

Reaction notes

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