Lithium Carbonate → HCID 59273042, compound

HRID 907035Notes

Reaction equation

HRID 907035 reaction equation
C1([C@:4]2([OH:12])[CH2:8][CH2:7][NH:6][C@H:5]2[CH:9](C)C)CC1.F[C:14]1[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[C:16]([C:22]([F:25])([F:24])[F:23])[CH:15]=1.[C:26](=O)([O-])[O-].[Li+].[Li+]>>[OH:12][C@H:4]1[CH2:8][C@@H:7]([CH3:26])[N:6]([C:14]2[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[C:16]([C:22]([F:25])([F:24])[F:23])[CH:15]=2)[C@H:5]1[CH3:9]

Participants

4

Reactant 3

HCID 11125Lithium CarbonateHCID 6050854-Fluoro-2-(trifluoromethyl)benzonitrileHCID 59273011(2S,3R)-3-cyclopropyl-2-isopropylpyrrolidin-3-ol

Product 1

HCID 59273042HCID 59273042, compound

Procedure

By an operation in the same manner as in Example 53 and using (2S,3S,5R)-2,5-dimethylpyrrolidin-3-ol 0.5 oxalate (153 mg), 4-fluoro-2-(trifluoromethyl)benzonitrile (277 mg) and lithium carbonate (200 mg), the title compound was obtained as colorless oil (yield: 121 mg, yield: 45%).

Sources & evidence

ORD record
ord-7b0ffd1ee6a441eca34e6f7e308c7729
Source dataset
uspto-grants-2011_09
Patent number
US08013008B2

Reaction notes

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