Lithium Carbonate → HCID 59273070, compound

HRID 907039Notes

Reaction equation

HRID 907039 reaction equation
[CH:1]1([C@:4]2([OH:12])[CH2:8][CH2:7][NH:6][C@H:5]2[CH:9](C)C)CC1.F[C:14]1[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[C:16]([C:22]([F:25])([F:24])[F:23])[CH:15]=1.[C:26](=O)([O-])[O-].[Li+].[Li+]>>[OH:12][C@@:4]1([CH3:1])[CH2:8][C@@H:7]([CH3:26])[N:6]([C:14]2[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[C:16]([C:22]([F:25])([F:24])[F:23])[CH:15]=2)[C@H:5]1[CH3:9]

Participants

4

Reactant 3

HCID 11125Lithium CarbonateHCID 6050854-Fluoro-2-(trifluoromethyl)benzonitrileHCID 59273011(2S,3R)-3-cyclopropyl-2-isopropylpyrrolidin-3-ol

Product 1

HCID 59273070HCID 59273070, compound

Procedure

By an operation in the same manner as in Example 53 and using (2S,3S,5R)-2,3,5-trimethylpyrrolidin-3-ol 0.5 oxalate (83 mg), 4-fluoro-2-(trifluoromethyl)benzonitrile (203 mg) and lithium carbonate (93 mg), the title compound was obtained as a colorless solid (yield: 61.9 mg, yield: 44%).

Sources & evidence

ORD record
ord-4a286456df53436bb459c161c96ce041
Source dataset
uspto-grants-2011_09
Patent number
US08013008B2

Reaction notes

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