Chlorosulfonyl isocyanate → 6-Methoxy-1H-indole-3-carbonitrile

HRID 907087노트

반응식

HRID 907087 반응식
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH:7]=[CH:8][NH:9]2)=[CH:5][CH:4]=1.ClS([N:16]=[C:17]=O)(=O)=O>CN(C=O)C>[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([C:17]#[N:16])=[CH:8][NH:9]2)=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 70918Chlorosulfonyl isocyanateHCID 766596-Methoxy-1H-indole

생성물 1

HCID 534011976-Methoxy-1H-indole-3-carbonitrile수율 85%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 6-methoxyindole (10.0 g, 68.0 mmol) in DMF (120 mL) was cooled to 0° C. and treated with chlorosulfonyl isocyanate (7.72 mL, 88.4 mmol). After the addition, the reaction mixture was stirred at this temperature for 1 h. The dark solution was poured into ice water (600 mL) and the light brown solid was collected by filtration, washed with additional H2O and dried to afford 9.9 g (85%) of 6-methoxy-1H-indole-3-carbonitrile as a light brown solid.

후처리

  1. additionAfter the addition
  2. filtrationthe light brown solid was collected by filtration
  3. washwashed with additional H2O
  4. customdried

출처 및 근거

ORD 기록
ord-4370ce09b3584c498ee5cb560e89bae2
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08013006B2

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