Trifluoroacetic acid → HCID 59426299, compound

HRID 907183Notes

Reaction equation

HRID 907183 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:15]([CH2:29][CH3:30])[C:16]3[C:21]([C:22]=2[C:23]#[N:24])=[CH:20][CH:19]=[C:18]([C:25]([F:28])([F:27])[F:26])[CH:17]=3)[CH2:10][CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[CH2:29]([N:15]1[C:16]2[C:21](=[CH:20][CH:19]=[C:18]([C:25]([F:27])([F:28])[F:26])[CH:17]=2)[C:22]([C:23]#[N:24])=[C:14]1[N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)[CH3:30]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59425186HCID 59425186, compound

Product 1

HCID 59426299HCID 59426299, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-(3-cyano-1-ethyl-6-trifluoromethyl-1H-indol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester (0.26 g, 6.1 mmol) was treated with TFA (5 mL) in dichloromethane (5 mL) for 1 hr at room temperature. After the removal of the volatiles, the residue was treated with saturated NaHCO3 and the precipitate was collected via filtration, washed with water thoroughly and dried in air to furnish essentially pure 1-ethyl-2-piperazin-1-yl-6-(trifluoromethyl)-1H-indole-3-carbonitrile (0.20 g, 100%).

Workup

  1. customAfter the removal of the volatiles
  2. additionthe residue was treated with saturated NaHCO3
  3. filtrationthe precipitate was collected via filtration
  4. washwashed with water thoroughly
  5. customdried in air

Sources & evidence

ORD record
ord-baa7c9a0bfd742ce851357bcf32e97fb
Source dataset
uspto-grants-2011_09
Patent number
US08013006B2

Reaction notes

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