HCID 131729161, compound → HCID 25020510, compound

HRID 907250Notes

Reaction equation

HRID 907250 reaction equation
Cl.[CH:2]1([NH:5][C:6](=[O:38])[C:7]2[CH:12]=[CH:11][C:10]([CH3:13])=[C:9]([C:14]3[CH:15]=[C:16]4[C:21](=[CH:22][CH:23]=3)[C:20](=[O:24])[N:19]([CH2:25][C:26]3[CH:31]=[CH:30][C:29]([C:32]5[CH2:33][CH2:34][NH:35][CH2:36][CH:37]=5)=[CH:28][CH:27]=3)[CH:18]=[CH:17]4)[CH:8]=2)[CH2:4][CH2:3]1>C(O)C.[Pd]>[CH:2]1([NH:5][C:6](=[O:38])[C:7]2[CH:12]=[CH:11][C:10]([CH3:13])=[C:9]([C:14]3[CH:15]=[C:16]4[C:21](=[CH:22][CH:23]=3)[C:20](=[O:24])[N:19]([CH2:25][C:26]3[CH:31]=[CH:30][C:29]([CH:32]5[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]5)=[CH:28][CH:27]=3)[CH:18]=[CH:17]4)[CH:8]=2)[CH2:3][CH2:4]1

Participants

4

Reactant 1

HCID 131729161HCID 131729161, compound

Product 1

HCID 25020510HCID 25020510, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

10% Pd/C (20 mg) was added to a solution of Example 7 (60 mg) in ethanol (20 mL) and the mixture subjected to hydrogenation at 3 Barr for 2 hours. The reaction mixture was filtered and evaporated under reduced pressure to give the title compound as the hydrochloride salt as a solid (50 mg).

Workup

  1. filtrationThe reaction mixture was filtered
  2. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-65cf78b4000d40afa82ea8981268fbf0
Source dataset
uspto-grants-2011_09
Patent number
US08012979B2

Reaction notes

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