反应详情

A mixture of 6-bromo-isochroman-1,3-dione (0.6 g) (product of step ii)) and 4-methoxybenzylamine (0.313 g) in toluene:acetic acid (4:1, 20 mL) was heated at reflux for 17 hours. The reaction mixture was evaporated and the residue was dissolved in dichloromethane before washing with 2N hydrochloric acid. The organic phase was dried, filtered and evaporated then triturated with diethyl ether to yield the sub-title compound (680 mg).

1. temperaturewas heated
2. temperatureat reflux for 17 hours
3. customThe reaction mixture was evaporated
4. dissolutionthe residue was dissolved in dichloromethane
5. washbefore washing with 2N hydrochloric acid
6. customThe organic phase was dried
7. filtrationfiltered
8. customevaporated
9. customthen triturated with diethyl ether