反应详情

A solution of 3-[2-(4-methoxy-benzyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-4-methyl-benzoic acid, methyl ester (product of step v)) (1.0 g) and cyclopropylamine (0.71 g) in tetrahydrofuran (3 mL) was treated with isopropylmagnesium chloride (2M in THF, 0.77 mL) and stirred at room temperature for 1 hour. The reaction mixture was quenched with aqueous ammonium chloride and extracted into ethyl acetate. The organic phase was dried, filtered and evaporated to yield the title compound as a solid (850 mg).

1. customThe reaction mixture was quenched with aqueous ammonium chloride
2. extractionextracted into ethyl acetate
3. customThe organic phase was dried
4. filtrationfiltered
5. customevaporated