Dimethylamine → N-Cyclopropyl-3-(2-(4-(2-(dimethylamino)ethoxy)benzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide

HRID 907268Notes

Reaction equation

HRID 907268 reaction equation
Cl[CH2:2][CH2:3][O:4][C:5]1[CH:35]=[CH:34][C:8]([CH2:9][N:10]2[CH:19]=[CH:18][C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:20]4[CH:21]=[C:22]([CH:29]=[CH:30][C:31]=4[CH3:32])[C:23]([NH:25][CH:26]4[CH2:28][CH2:27]4)=[O:24])[CH:16]=3)[C:11]2=[O:33])=[CH:7][CH:6]=1.[CH3:36][NH:37][CH3:38]>>[CH:26]1([NH:25][C:23](=[O:24])[C:22]2[CH:29]=[CH:30][C:31]([CH3:32])=[C:20]([C:15]3[CH:16]=[C:17]4[C:12](=[CH:13][CH:14]=3)[C:11](=[O:33])[N:10]([CH2:9][C:8]3[CH:7]=[CH:6][C:5]([O:4][CH2:3][CH2:2][N:37]([CH3:38])[CH3:36])=[CH:35][CH:34]=3)[CH:19]=[CH:18]4)[CH:21]=2)[CH2:27][CH2:28]1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 575518303-(2-(4-(2-Chloroethoxy)benzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide

Product 1

HCID 25020015N-Cyclopropyl-3-(2-(4-(2-(dimethylamino)ethoxy)benzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide

Procedure

A solution of the product of step ii) (95 mg) in dimethylamine (5M in ethanol, 1.5 mL) was heated using microwave irradiation at 100° C. for 90 minutes.

Workup

  1. custommicrowave irradiation at 100° C. for 90 minutes

Sources & evidence

ORD record
ord-90d59af96cbb4643ab0f55fea79224e6
Source dataset
uspto-grants-2011_09
Patent number
US08012979B2

Reaction notes

Loading…