HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → N-Cyclopropyl-3-(2-(4-(2-(dimethylamino)ethoxy)benzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | 3-(2-(4-(2-Chloroethoxy)benzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide | HCID 57551830 | — |
| Product | N-Cyclopropyl-3-(2-(4-(2-(dimethylamino)ethoxy)benzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide | HCID 25020015 | — |
Reaction Steps
A solution of the product of step ii) (95 mg) in dimethylamine (5M in ethanol, 1.5 mL) was heated using microwave irradiation at 100° C. for 90 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08012979B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-90d59af96cbb4643ab0f55fea79224e6 |
| Source note | uspto-grants-2011_09 |