Diisopropylethylamine → 6-Bromo-2-(cyclopropylmethyl)-1-oxo-1,2-dihydroisoquinoline-4-carboxylic acid, methyl ester

Participants

Reaction Steps

A mixture of the product of step ii) (5.5 g), cyclopropylmethanamine hydrochloride (2.09 g) and N,N-diisopropylethylamine (5.1 mL) in methanol (40 mL) was heated at reflux for 17 hours. The reaction mixture was allowed to cool to room temperature and filtered. The solid was washed with methanol and dried under vacuum at 60° C. to yield the sub-titled compound (4.55 g)

Provenance & Evidence