反应详情

A mixture of the product of step ii) (5.5 g), cyclopropylmethanamine hydrochloride (2.09 g) and N,N-diisopropylethylamine (5.1 mL) in methanol (40 mL) was heated at reflux for 17 hours. The reaction mixture was allowed to cool to room temperature and filtered. The solid was washed with methanol and dried under vacuum at 60° C. to yield the sub-titled compound (4.55 g)

1. temperaturewas heated
2. temperatureat reflux for 17 hours
3. filtrationfiltered
4. washThe solid was washed with methanol
5. customdried under vacuum at 60° C.