Benzylamine → 2-Benzyl-6-bromo-1-oxo-1,2-dihydroisoquinoline-4-carboxylic acid, methyl ester

Participants

Reaction Steps

A mixture of the product of Example 37 step ii) (5 g) and benzylamine (3 mL) in methanol (20 mL) was heated at reflux for 40 hours. The reaction was concentrated to half volume, then treated with acetonitrile. The sub-title compound was collected by filtration, washing with acetonitrile (5.30 g).

Provenance & Evidence