Cesium carbonate → HCID 57551774, compound

HRID 907286Notes

Reaction equation

HRID 907286 reaction equation
C(=O)([O-])[O-].[Cs+].[Cs+].[Br:7][C:8]1[CH:9]=[C:10]2[C:15](=[CH:16][CH:17]=1)[C:14](=[O:18])[NH:13][CH:12]=[CH:11]2.Br[CH2:20][CH:21]1[CH2:23][CH2:22]1>O>[Br:7][C:8]1[CH:9]=[C:10]2[C:15](=[CH:16][CH:17]=1)[C:14](=[O:18])[N:13]([CH2:20][CH:21]1[CH2:23][CH2:22]1)[CH:12]=[CH:11]2

Participants

5

Reactant 3

HCID 10796Cesium carbonateHCID 81503BromomethylcyclopropaneHCID 158851826-Bromoisoquinolin-1(2H)-one

Product 1

HCID 57551774HCID 57551774, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

Cesium carbonate (2.62 g), intermediate 1 (1.5 g) and (bromomethyl)cyclopropane (0.8 mL) were stirred and heated at 50° C. for 4 hours. The mixture was allowed to cool then poured into water and extracted with ethyl acetate. The organic extracts were combined dried and evaporated under reduced pressure. The residue was triturated with ether and the sub-titled compound isolated by filtration (1.0 g).

Workup

  1. temperatureto cool
  2. extractionextracted with ethyl acetate
  3. customThe organic extracts were combined dried
  4. customevaporated under reduced pressure
  5. customThe residue was triturated with ether

Sources & evidence

ORD record
ord-26179bcdb3244752b2156cc2963b4418
Source dataset
uspto-grants-2011_09
Patent number
US08012979B2

Reaction notes

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