反应详情

温度

70 °C

To a solution of the product of Example 47 step i) (0.65 g) in methanol (10 mL) was added a 5M aqueous solution of sodium hydroxide (3.53 mL) and the mixture stirred at 70° C. for 2 hours. The reaction was concentrated to approximately half volume and acidified with acetic acid. The sub-title compound was collected by filtration (0.36 g).

1. concentrationThe reaction was concentrated to approximately half volume
2. filtrationThe sub-title compound was collected by filtration (0.36 g)