Sodium Hydroxide → 2-Benzyl-6-bromo-1-oxo-1,2-dihydroisoquinoline-4-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

To a solution of the product of Example 47 step i) (0.65 g) in methanol (10 mL) was added a 5M aqueous solution of sodium hydroxide (3.53 mL) and the mixture stirred at 70° C. for 2 hours. The reaction was concentrated to approximately half volume and acidified with acetic acid. The sub-title compound was collected by filtration (0.36 g).

Provenance & Evidence