Hexahydro-1,4-diazepine → 3-(4-((1,4-Diazepan-1-yl)methyl)-2-(cyclopropylmethyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-5-fluoro-4-methylbenzamide

HRID 907321Notes

Reaction equation

HRID 907321 reaction equation
[CH:1]1([NH:4][C:5](=[O:31])[C:6]2[CH:11]=[C:10]([F:12])[C:9]([CH3:13])=[C:8]([C:14]3[CH:15]=[C:16]4[C:21](=[CH:22][CH:23]=3)[C:20](=[O:24])[N:19]([CH2:25][CH:26]3[CH2:28][CH2:27]3)[CH:18]=[C:17]4[CH:29]=O)[CH:7]=2)[CH2:3][CH2:2]1.[NH:32]1[CH2:38][CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1>>[N:32]1([CH2:29][C:17]2[C:16]3[C:21](=[CH:22][CH:23]=[C:14]([C:8]4[CH:7]=[C:6]([CH:11]=[C:10]([F:12])[C:9]=4[CH3:13])[C:5]([NH:4][CH:1]4[CH2:2][CH2:3]4)=[O:31])[CH:15]=3)[C:20](=[O:24])[N:19]([CH2:25][CH:26]3[CH2:28][CH2:27]3)[CH:18]=2)[CH2:38][CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1

Participants

3

Reactant 2

HCID 68163Hexahydro-1,4-diazepineHCID 57551841N-Cyclopropyl-3-(2-(cyclopropylmethyl)-4-formyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide

Product 1

HCID 250204003-(4-((1,4-Diazepan-1-yl)methyl)-2-(cyclopropylmethyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-5-fluoro-4-methylbenzamide

Procedure

The title compound was prepared as a solid according to the method of Example 75 step ii) using product of Example 75 step i) and [1,4]diazepane.

Sources & evidence

ORD record
ord-9c7ca4d868f04a128f5a6143f1eaf823
Source dataset
uspto-grants-2011_09
Patent number
US08012979B2

Reaction notes

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