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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 907321Generated: October 29, 2026

Hexahydro-1,4-diazepine → 3-(4-((1,4-Diazepan-1-yl)methyl)-2-(cyclopropylmethyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-5-fluoro-4-methylbenzamide

https://huagongshe.com/reaction/907321

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHexahydro-1,4-diazepineHCID 68163—
ReactantN-Cyclopropyl-3-(2-(cyclopropylmethyl)-4-formyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamideHCID 57551841—
Product3-(4-((1,4-Diazepan-1-yl)methyl)-2-(cyclopropylmethyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-5-fluoro-4-methylbenzamideHCID 25020400—

Reaction Steps

The title compound was prepared as a solid according to the method of Example 75 step ii) using product of Example 75 step i) and [1,4]diazepane.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08012979B2
Source datasetuspto-grants-2011_09
ORD IDord-9c7ca4d868f04a128f5a6143f1eaf823
Source noteuspto-grants-2011_09