HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexahydro-1,4-diazepine → 3-(4-((1,4-Diazepan-1-yl)methyl)-2-(cyclopropylmethyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-5-fluoro-4-methylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexahydro-1,4-diazepine | HCID 68163 | — |
| Reactant | N-Cyclopropyl-3-(2-(cyclopropylmethyl)-4-formyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide | HCID 57551841 | — |
| Product | 3-(4-((1,4-Diazepan-1-yl)methyl)-2-(cyclopropylmethyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-5-fluoro-4-methylbenzamide | HCID 25020400 | — |
Reaction Steps
The title compound was prepared as a solid according to the method of Example 75 step ii) using product of Example 75 step i) and [1,4]diazepane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08012979B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-9c7ca4d868f04a128f5a6143f1eaf823 |
| Source note | uspto-grants-2011_09 |